Mempro™ Virus-like Particles (VLPs) Application

Virus-like particles (VLPs) have developed to be a widely applied technology, faciliating biology and medicine research dramatically. Over the recent yrars, Creative Biostructure has focused on VLPs application and established an outstanding VLPs technology platform far beyond the field of vaccinology. We provide the best services for various VLPs applications with an expanding spectrum.

Figure 1. Protein delivery system using VLPs. (PNAS, 2011)

•  Mempro™ Virus-like Particles (VLPs) in Vaccines
VLPs are non-infectious because there is no viral genetic material in them and they can not replicate, which makes VLPs very useful in vaccine industry. Creative Biostructure are expertized in generation vaccine antigens by our VLPs platform in various expression systems. We are your reliable partner to design and produce custom VLP-based vaccines as safer and more effective alternatives against conventional vaccines.

•  Mempro™ Virus-like Particles (VLPs) in Lipoparticle Technology
Lipoparticles are specialized VLPs which contain an interested integral membrane protein in high concentration. Based on our advanced Mempro™ Membrane Protein Platform and Mempro™ VLPs Platform, Creative Biostructure can provide highly purified and stable VLPs contain a broad variety of membrane proteins in the form of lipoparticles. Our lipoparticle technology provide a platform for various applications like antibody screening, ligand binding assays, and immunogen production, etc.

•  Mempro™ Virus-like Particles (VLPs) as Delivery Systems
Mempro™ VLPs Platform are able to apply VLPs as delivery systems to transport numerous compounds including protein and peptide, DNA, siRNA and drugs. VLPs can be used as a carrier for protein and peptide both in vivo and in vitro; delivery of DNA by VLPs is very useful for gene therapy and vaccine decelopment; delivery of siRNA by VLPs can overcome the mainly challenge of low stability and poor cell- penetrating ability of siRNA; delivery of drugs by VLPs prevent drugs to degrade in blood and increase the targeting effects.

•  Mempro™ Virus-like Particles (VLPs) in Bioimaging
Creative Biostructure can provide VLPs chemical modification services such as probe conjugation for bioimaging application both in vivo and in vitro because VLPs has a high biological compatibility.

•  Mempro™ Virus-like Particles (VLPs) in Cell Targeting
Creative Biostructure can give specificity to cell targeting by attaching the targeting ligands to VLPs. By using other molecules such as vitamins, carbohydrates proteins (mainly antibodies), peptides, and nucleic acids (aptamers), we can also achieve cell targeting.

We provide various Mempro™ Virus-like Particles (VLPs) Application services, also including cell targeting, biosensor, and chimeric VLPs production, etc. Please feel free to contact us for a detailed quote.

References:
Z. Shirbaghaee, et al. (2016). Different Applications of Virus-Like Particles in Biology and Medicine: Vaccination and Delivery Systems. Biopolymers,105: 113–132.
S. J. Kaczmarczyk, et al. (2011). Protein delivery using engineered virus-like particles. PNAS, 108(41), 16998–17003.
J. O. Josefsberg, et al. (2012). Vaccine Process Technology. Biotechnol. Bioeng.,109: 1443–1460.