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Creative Biostructure now can provide a collection of tools and analysis package for biomolecular structure determination, refinement, and analysis from crystallographic, EM or NMR data. In the structural biology field, to reveal a dedicated and reliable structure of a biomolecule, research data is acquired, interpreted, published, reused, and sometimes eventually discarded. Creative Biostructure helps the development of appropriate infrastructural services, ones which make it easier and timesaving for researchers to collect, read, and process the data and obtain the expected and target structure results.
With this deliverable, the project has reached or the deliverable has contributed to the following objectives, including but not limited to:
|1||Provide analysis solutions for the different Structural Biology approaches.|
|2||Provide automated pipelines to handle multi-technique datasets in an integrative manner.|
|3||Provide integrated data management for single and multi-technique projects, based on existing e-infrastructure.|
The physical infrastructure for X-ray crystallography structural biology includes synchrotrons, which are affordable by a nation. There are 47 in the world (lightsources.org). Each synchrotron provides several beamlines for experiments, usually including several optimized for macromolecular X-ray crystallography, often some for other structural biology techniques including SAXS (Small-Angle X-Ray Scattering) and CD (Circular Dichroism), and usually some beamlines for material sciences and other non-biological applications. Creative Biostructure has access to the most modern and popularly used synchrotron X-ray resources, such as ALS, SSRL, CAMD, Photon Factory, SSRF, etc. The phase problem is the trickiest part in determining the crystal structure, for which we can support multiple crystallography phase determination techniques.
Improvements in microscopes, direct electron detectors, and processing software have led to a rapid increase in the number of high-resolution cryo-EM structures – the "resolution revolution". This has led in turn to significant investments in electron microscopes around the world. Structural biologists in Creative Biostructure are working on harder targets: fewer single proteins, larger macromolecular assemblies, more membrane proteins.
Figure 1 shows the increasing proportion of PDB entries belonging to these more difficult categories.
Creative Biostructure has access to the Structural Biology NMR Resource to obtain high-resolution solution NMR spectrometers ranging from 300 MHz to 900 MHz in field strength. These are used for small molecule analysis and studies of macromolecular structure, dynamics, and function. Our highly trained associates assist in the collection and interpretation of routine data, for training in instrument usage, for performing data processing and interpretation and to partner for more extended collaborative studies of protein or nucleic acid structure and dynamics.
Besides, we can also provide other structural data processing and interpretation services such as protein domain prediction, combining X-ray crystallography and solution NMR data, as well as image and data analysis Please feel free to contact us for more information or a detailed quote.