Liposomes in Cancer Therapy

Creative Biostructure is the industry leading supplier in liposome manufacturing and analysis. Our advanced liposome platform is equipped with the most up-to-date instruments to support a diverse range of research goals. Noticing the tremendous therapeutic potentials offered by targeted delivery, several liposomal formulations have been developed to implement the idea of precise therapy. To meet the specific needs of our clients worldwide, Creative Biostructure offers customized service for liposome production and cargo encapsulation.

Why use liposomes in cancer therapy?

Chemotherapy remains the most commonly used approach in cancer treatment despite the severe side effects caused by harsh drugs. Bio-drugs, on the other hand, offer enhanced selectivity and efficacy, and hence considered as a promising alternative for chemotherapy in a number of cancer types. However, a major drawback of bio-drugs is that they often suffer from poor bioavailability and compromised PK/PD properties due to relatively large molecular weight. In designing the next generation cancer treatment, extensive effort has been made to find novel therapeutic agents as well as delivery tools. One way to circumvent the limitations associated with chemotherapy is to combine a functional vesicle with the drug for targeted delivery and controlled release. A good example is liposome – the most common type of lipid nanoparticle that is biodegradable, biocompatible, and offers a useful tool of drug delivery, particularly for the highly toxic drugs. Nowadays, an increasing number of liposomes are extensively used for drug delivery to cancer cells. The next generation of drug delivery liposome will focus more on tumor recognition, including true molecular targeting, immunoliposomes.

Figure 1. Scheme of the of biotinylated liposomes induced by the tetrameric streptavidin protein. (D. Lombardo, et al., 2016).

In recent years, great progress has been made in the discovery of liposomal delivery systems with an improved potential for cancer treatment. Creative Biostructure masters several key techniques to perfect the cancer drug delivery system. Our liposome services include but are not limited to:

• Design and manufacture customized liposomal drug formulation.
• Liposome and encapsulated drug characterization.
• Pharmacokinetics and pharmacodynamics study of liposomal drug in vivo and in vitro.

Creative Biostructure is devoted to provide you liposome products and services with premium quality and reliability. Our Liposome platform is designed to routinely provide custom liposome preparations according to your requirements. Please contact us for more information.

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References

1. Pranali P Deshpande, et al. (2013). Current trends in the use of liposomes for tumor targeting. Nanomedicine, 8(9):1509-1528.
2. Himanshu Pandey, et al. (2016). Liposome and their applications in cancer therapy. Brazilian archives of biology and technology, 59: e16150477.
3. A. Akbarzadeh, et al. (2013). Liposome: classification, preparation, and applications. Nanoscale Research Letters, 8: 102.