High-Resolution Magic-Angle Spinning (HRMAS) NMR Service

High-resolution magic-angle spinning (HRMAS) NMR is a rapidly developed technique in NMR spectroscopy, whose main characteristic is to allow the significant reduction of anisotropy in semisolid materials and obtain high-resolution NMR spectra, when a rotor containing the material is placed at the magic angle to the magnetic field and spun at high frequency. After decades of development, this technique is now widely used for a variety of biomedical applications as an intact biological material analysis method. For example, HRMAS NMR metabolomics has been applied to studying human disease states, including cancers, metabolic diseases, transplantation medicine, brain diseases and adiposity. These findings help us to better understand the metabolic characteristics of disease and contribute to diagnosis, opportune windows for treatment, and prognostication. In addition, metabolomic studies of foods and plants also benefit from this technology.

Creative Biostructure offers a comprehensive NMR spectroscopy technology platform, our advanced platform and experts with years of experience performing HRMAS NMR experiments can help you evaluate metabolite profiles of intact tissue with high spectral resolution.

Figure 1. HRMAS NMR-based fingerprints determination in the medicinal plant berberis laurinas (Ali S.; et al. 2020)

Advantages of Our HRMAS NMR Service

• It is a non-destructive technique that does not require any extraction or pretreatment, and it requires the provision of a small number of samples to obtain metabolite profiles of tissues.
• Our advanced methods better preserve sample integrity, minimize degradation, and allow measurement of delicate tissues.
• In addition to the typical HRMAS NMR analysis protocol, we can also use typical pulse sequence programs and quantization methods.
• We ensure high quality in every step of the HRMAS NMR spectroscopy workflow, including sample preparation, collection procedures, measurement parameters, spectral processing, and metabolite quantification and statistical analysis.

In the field of metabolomics, HRMAS NMR spectroscopy has been established as a powerful tool for both targeted and untargeted metabolite profiling, and biomedical fields benefit from scientific research based on this technique. Creative Biostructure not only supports a wide range of HRMAS NMR applications in the biomedical field, but also provides HRMAS NMR analysis of agricultural foods such as dairy products, fruits, vegetables, cereals, fish and meat to customers in the food chemistry industry. If you are interested in our services, please contact us for more details. Our customer service representatives are available 24 hours a day from Monday to Sunday.

Ordering Process

References

1. Tilgner M.; et al. High-resolution magic angle spinning (HRMAS) NMR methods in metabolomics. NMR-Based Metabolomics. Humana, New York, NY, 2019: 49-67.
2. Ali S.; et al. High-Resolution Magic Angle Spinning (HR-MAS) NMR-Based Fingerprints Determination in the Medicinal Plant Berberis laurina. Molecules. 2020, 25(16): 3647.