Photo-activated Liposomes Production

Creative Biostructure is particularly professional in providing the first-class customized service. We have built several specific platforms to offer superb liposome manufacture service. Noticing the promising potentials of liposomes used in target drug delivery systems, we have developed a couple of technologies, including photo-activated liposome technology that enhances drug biodistribution and bioavailability using light as stimulus.

How Photo-activated Liposomes Work

Liposomes constituted from light-sensitive lipids have been explored since early 1980s. Membrane permeabilization of these light-controlled liposomes are induced upon light exposure of specific wavelength to target drug release. A successful example of photo-activated liposome formulation in clinical use now is Visudyne therapy to treat age-related macular degeneration of (AMD) in patients. In this formulation, essential drug release is followed by non-photothermal treatment with a 689 nm laser source after injection. As a candidate for sustained and on demand drug delivery, photo-activated liposomes gained more attention with its various parameters, such as exposure time, wavelength, beam diameter, and laser intensity to adapt to different purposes. Creative Biostructure can facilitate such effort with high quality service.

Photo-activated Liposomes Applications

The fact that spatial and temporal release of nanoparticle-encapsulated drugs is triggered at the site of action calls for attention to further improve drug delivery sustainability, and Photo-Stabilized Liposomes is one of the approaches to sustained drug delivery utilizing photoreactive lipids. Photo-activated Liposomes with built-in photo triggering properties will have significant impact on cancer therapy and other related diseases.

Figure 1. Phototriggerable liposome assembly. (Pharmaceutics, 2014)

According to the diverse mechanisms of release, we offer the following liposome synthesis services.

• Light-induced Oxidation Liposomes: Use reactive oxygen species to light-induce oxidization of unsaturated lipids, then induce formation of pores in membrane bilayers.
• Photocleavable Liposomes: Design susceptible-to-light amphiphiles moiety (typically in the UV range) to generate breakdown products that can destabilize liposome membrane.
• Photopolymerizable Liposomes: Design photopolymerizable phospholipid molecules that photo-crosslinking under light induce and rendering the unstable bilayers.
• Photoisomerization Liposomes: Design photoisomerization moiety, the conformational change destabilizes the lipid membrane and allows for release.
• Molecular Dyes Liposomes: Using hydrophilic dye or hydrophobic dye to achieve cargo release under a wide array of light wavelengths.
• Gold Nanoparticles Liposome: Development of single nanometer size gold to mediate photothermal conversion in liposomes.

Creative Biostructure has decade-long-experienced experts which support the liposome development in a professional way. We are good at lipid modifications as well as combining the nanomaterials to prepare functional liposomes. Creative Biostructure is absolutely the best cooperator for your research. Please contact us for more information.

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References

1. Anu Puri. (2014) Phototriggerable liposomes: current research and future perspectives. Pharmaceutics. 6:1-25.
2. Sarah J. Leung, Marek Romanowski. (2012) Light-activated content release from liposomes. Theranostics. 2:1020-1036.
3. Tatu Lajunen, Riikka Nurmi, Leena Kontturi et al. (2016) Light activated liposomes: Functionality and prospects in ocular drug delivery. Journal of Controlled Release. 244: 157-166.