Citations
Publications, Patents, and Book Chapters Citing Our Work
We provided high-quality service to numerous customers. A long list of papers have been published in Peer-reviewed Publications journals and a lot of patent applications have been approved or in process with custom products or services from us. Below are some selected patents and papers to give you an idea of how our products and custom services have been applied as part of leading edge in life science research in academia and industry. These publications are sorted according to different divisions of our company.
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Jankelow, Aaron, et al. "Multiplexed electrical detection of whole viruses from plasma in a microfluidic platform." Analyst (2024).
… B19V virus-like particles (VLPs) (Cat# CBS-V088-C) were obtained from Creative Biostructure …
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Marino, Claudia, et al. "APOE Christchurch‐mimetic therapeutic antibody reduces APOE‐mediated toxicity and tau phosphorylation." Alzheimer's & Dementia (2023).
… Recombinant Fab region including the complementarity-determining regions (CDRs) of the 7C11.chIgG1 antibody was produced as fee-for-service by Creative BioStructure (Shirley, NY, USA) … … Binding kinetics between the purified Fab-7C11 protein and recombinant ApoE4 were quantified in PBS solution using a Biacore 3000 instrument (GE Healthcare) as a fee-for-service with Creative BioStructure and according to previously published procedures … … We resolved the three-dimensional crystal structure of purified 7C11.IgGFab protein as a fee-for-service with Creative BioStructure …
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Custom Protein Production Surface Plasmon Resonance (SPR) X-ray Crystallography Services
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Hrušková, Helena, Roman Řemínek, and František Foret. "Offline preparative separation methods based on electromigration: An overview and current trends." TrAC Trends in Analytical Chemistry (2023): 117428.
… Commercial free-flow electrophoretic instruments, e.g., Free-Flow electrophoresis systems marketed by FFE Service GmbH (Feldkirchen, Germany) or Creative Biostructure (Shirley, NY, USA) …
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Goc, Anna, et al. "Inhibition of α-hemolysin activity of Staphylococcus aureus by theaflavin 3, 3’-digallate." Plos one 18.8 (2023): e0290904.
… To determine binding affinity of native Hla with TF3, SPR binding assay was performed (Creative Biostructure, Shirley, NY) …
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Goc, Anna, et al. "Phytochemicals and micronutrients in suppressing infectivity caused by SARS-CoV-2 virions and seasonal coronavirus HCoV-229E in vivo." European Journal of Microbiology and Immunology (2023).
… SARS-CoV-2 viral like particles (VLPs) were obtained from Creative Biostructure (Shirley, NY, USA) …
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Molla, Mohammad Habibur Rahman, and Mohammed Othman Aljahdali. "Marine-derived sea urchin compounds as potential anti-cancer drug candidate against colorectal cancer: In silico and in vitro studies." Saudi Journal of Biological Sciences 30.9 (2023): 103748.
… Easily predicting the hydrophobicity, solubility, permeability, etc. of substances and applying predictive models for blood–brain barrier (BBB) permeability, medication bioavailability, cytochrome P450, hERG toxicity, and more are possible using Creative Biostructure …
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Kwon, Taek Hun, and Tae Gyun Kim. "Purification, crystallization, and preliminary structural analysis of multivalent immunogenic effector protein-anchored SARS-CoV-2 RBD." bioRxiv (2023): 2023-08.
… Crystallization BmRecA-RBD protein was initially crystallized using various screening kits from commercial company as Hampton Research, Creative Biostructure …
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Kang, IL-Ho, et al. "A novel mechanism of herbicide action through disruption of pyrimidine biosynthesis." Proceedings of the National Academy of Sciences 120.48 (2023): e2313197120.
… Creative Biostructure (Shirley, NY) provided the X-ray crystallographic support …
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Lodaya, Rushit N., et al. "A Self-Emulsified Adjuvant System Containing the Immune Potentiator Alpha Tocopherol Induces Higher Neutralizing Antibody Responses than a Squalene-Only Emulsion When Evaluated with a Recombinant Cytomegalovirus (CMV) Pentamer Antigen in Mice." Pharmaceutics 15.1 (2023): 238.
… To understand the morphology of the oil droplets in SE-AS44 compared to AS03, we collaborated with Creative Biostructure (Shirley, NY, USA) to obtain cryo-EM images and size …
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Somasundaram, Dr N. "A Review on Liposomes as a Drug Delivery System." International Journal of Pharmacy and Analytical Research (IJPAR).Vol-12(3) 2023: 346-357.
… Known for high performance and efficient development in liposome delivery systems, Creative Biostructure has extended the applications into the cosmetic industry …
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Monferrer, Alba, et al. "Broad-spectrum virus trapping with heparan sulfate-modified DNA origami shells." ACS nano 16.12 (2022): 20002-20009.
… VLPs were purchased from Creative Biostructure …
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Lodaya, Rushit N., et al. "A Self-Emulsified Adjuvant System Containing Alpha-Tocopherol Induced Higher Neutralizing Antibody Responses than a Squalene Only Emulsion Against a Recombinant Cytomegalovirus (CMV) Pentamer Antigen." (2022).
… To understand the morphology of the oil droplets in SE-AS44 compared to AS03, we collaborated with Creative Biostructure (Shirley, NY) to obtain cryo-EM images and size analysis for …
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Kim, Tae Gyun, et al. "Yeast nicotinate-nucleotide pyrophosphorylase in complex with its ligand: Crystallization and Preliminary structural approaches." bioRxiv (2022): 2022-11.
… Apo NMnPP protein was initially crystallized using various screening kits from commercial company as Hampton Research, Creative Biostructure …
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Goc, Anna, et al. "Linoleic acid binds to SARS-CoV-2 RdRp and represses replication of seasonal human coronavirus OC43." Scientific Reports 12.1 (2022): 19114.
… SPR binding assay, which measures binding affinity KD as well kinetic parameters ka and kd of human RdRp protein, with LA as the ligand, was utilized, where RdRp protein was printed onto the chip and the analyte was LA at different concentrations (Creative Biostructure, Shirley, NY) … … It is a complex structure of SARS-CoV-2 RNA polymerase with double-strand RNA fragments (Creative Biostructure, Shirley, NY) …
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Weissman, Alex D. "AI in Proteomics: A Comparison Between Crystallographic and in silico Methods of Protein Modeling." (2022).
… Our purified samples of NSP4 were then sent to Creative Biostructure for crystallization condition determination …
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Yang, Quan-En, et al. "Rapid quality control assessment of adeno-associated virus vectors Via stunner." GEN Biotechnology 1.3 (2022): 300-310.
… Empty versus full viral particle assays by TEM were performed by Creative Biostructure …
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Cryo-EM for Viral Particle Identification and Characterization
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Lukose, Jijo, Santhosh Chidangil, and Sajan D. George. "Optical technologies for the detection of viruses like COVID-19: Progress and prospects." Biosensors and Bioelectronics 178 (2021): 113004.
… Creative Biostructure has been using their commercial SPR systems to evaluate the binding affinity between SARS-CoV-2 S protein and human ACE2 receptors. …
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Andronico, Luca A., et al. "Sizing extracellular vesicles using membrane dyes and a single molecule-sensitive flow analyzer." Analytical chemistry 93.14 (2021): 5897-5905.
… For selection of membrane dye, we used big liposomes (B-Lipo, from Creative Biostructure; DOPC:CHOL 55:45 mol/mol) whose distribution was centered at 130 nm …
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Al-shubaily, Fawzia A., and Maryam H. Al-Zahrani. "Characterization and Fine Structure of Exosomes." Role of Exosomes in Biological Communication Systems (2021): 27-75.
… Creative Biostructure provides a sensitive technology for exosome characterization to gain more information and accelerating the use of exosome biology in diagnostic tests or clinical …
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Alejaldre, Lorea, Joelle N. Pelletier, and Daniela Quaglia. "Methods for enzyme library creation: Which one will you choose? A guide for novices and experts to introduce genetic diversity." BioEssays 43.8 (2021): 2100052.
… Other companies that offer library generation services include Creative Biostructure …
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Albadari, Najah, et al. "Synthesis and biological evaluation of selective survivin inhibitors derived from the MX-106 hydroxyquinoline scaffold." European Journal of Medicinal Chemistry 224 (2021): 113719.
… We are currently working with a CRO (Creative Biostructure, Inc) to optimize the crystallization condition in order to obtain the crystal structures of survivin protein in complexes with this …
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Liang, Chenyu, et al. "Exosomes of human umbilical cord MSCs protect against hypoxia/reoxygenation-induced pyroptosis of cardiomyocytes via the miRNA-100-5p/FOXO3/NLRP3 pathway." Frontiers in Bioengineering and Biotechnology 8 (2021): 615850.
… Extracted exosomes were checked using transmission electron microscopy (TEM) (MagHelix, Creative Biostructure, Shirley, NY) …
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Shewell, Lucy K., et al. "All major cholesterol-dependent cytolysins use glycans as cellular receptors." Science advances 6.21 (2020): eaaz4926.
… We thank Creative Biostructure (NY, USA) for protein chemical shift assignment …
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Bickmore, Diana C., and John J. Miklavcic. "Characterization of extracellular vesicles isolated from human milk using a precipitation-based method." Frontiers in nutrition 7 (2020): 22.
… Fatty acid analysis was performed by Creative Biostructure (Shirley, NY USA) …
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Madrigal, Jasmine L., and Melissa K. Jones. "Quantifying human norovirus virus-like particles binding to commensal bacteria using flow cytometry." JoVE (Journal of Visualized Experiments) 158 (2020): e61048.
… VLP Creative Biostructure CBS-V700 human norovirus virus like particle, VLPs were generated using the baculovirus system and resuspended in phosphate buffered saline with 10% …
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Biosystems, Emerald. "Products or services in software, drug discovery or protein production, purification and analysis." Nature 465 (2010): 10.
… Creative Biostructure Services to obtain and analyse crystallographic and NMR structures of macromolecules …
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