Creative Biostructure to Present at AACR Annual Meeting 2024 | April 5-10, 2024 | Booth #2953 
Nanosphere Services
Nano-drug delivery system is a very promising system that has shown excellent efficacy for certain diseases. Among them, nanospheres are solid colloidal particles composed of polymeric substances with particle sizes in the range of 10-100 nm. Nanospheres are of matrix skeleton type and are mainly prepared from polymeric materials such as polylactic acid, polypropylene cross-ester-ethyl cross-ester, chitosan, and gelatin. They can be used to encapsulate hydrophilic drugs and hydrophobic drugs. Depending on the material properties, it is suitable for targeting by different routes of drug delivery and for slow and controlled release by intramuscular or subcutaneous injection.
Due to its huge specific surface area, it has strong adsorption properties. If special functional groups are linked on the surface of nanospheres so that they can selectively adsorb certain substances, this property makes it a key material for drug separation and purification. Nanospheres themselves have no pharmacological effect and do not react chemically with drugs. As a drug carrier, it has the advantages of improving drug utilization and selectivity, reducing the damage of drugs to normal tissues, and reducing toxic side effects. Also, it can deliver the drug to the lesion site in a targeted manner to achieve targeted drug delivery.
Method of preparing nanospheres
- Prepared by the polymerization reaction with different monomers. For example, emulsion polymerization and interfacial polymerization method.
- Carrier material dispersion method. The drug and the polymeric carriers are mixed and dispersed by the physicochemical action of the dispersing medium and the solvent. Commonly used methods include ultrasonic emulsification-solvent volatilization and salt precipitation coalescence.
Characteristics of different types of nanosphere drug delivery systems
| Types | Features |
| Poly (lactic acid-glycolic acid) copolymer (PLGA) nanospheres | They can adapt to various hydrophilic, hydrophobic, macromolecular, and small molecule drugs, solve the problem of low bioavailability of insoluble drugs, and have high biosafety. |
| Gold nanospheres | With excellent optical properties, on the one hand, it enhances the electromagnetic field around the gold nanosphere, producing strong bright spots that can be applied to imaging. On the other hand, it converts the incident energy into heat and increases the local temperature around the near-gold nanopores, which can be applied to photothermal therapy to assist the emission treatment, especially for deep tumor treatment. Meanwhile, gold nanospheres have better biocompatibility, lower biotoxicity, and surface adsorption carrying capacity. It can modify functional molecules such as target molecules, drug molecules, and imaging contrast agents. |
| Magnetic Fe3O4-SiO2 nanospheres | Integrates the magnetic responsiveness of Fe3O4 with the large specific surface area of silica. The particle size can be controlled and the surface can be easily modified in a single particle. They have shown great potential for imaging, diagnostics, loading of target molecules, imaging agents, and targeted drug delivery applications. |
| Drug-loaded cavity calcium carbonate nanospheres | They have good pH responsiveness, significant slow-release characteristics, low toxicity, and good hepatic targeting and hepatic tumor targeting ability and anti-tumor effects. |
Creative Biostructure is committed to providing more services in nanosphere preparation and synthesis, transmission electron microscopy and particle size distribution analysis of drug-loaded nanospheres, and in vitro release performance testing. We have extensive experience in nanosphere drug delivery, vaccine vectors, and cancer therapeutics to quickly help you achieve breakthrough research. Please contact our staff to learn how we can do this.
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