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Obtaining diffraction-quality crystals is a prerequisite for solving any macromolecular structure through X-ray diffraction approaches. Once the appropriate crystals are obtained, it is necessary to submit them to the process of X-ray diffraction data acquisition. Diffraction data collection is the final experimental stage of crystal structure analysis. Optimal measurements and accurate diffraction data make subsequent structural analysis steps easier and lead to the final reconstruction of the three-dimensional (3D) structure model more accurate and reliable.
Creative Biostructure exploits powerful Rigaku X-ray equipment (for testing and optimization) and synchrotron radiation (for formal X-ray diffraction data collection) to support X-ray diffraction data acquisition. Our crystallographers have a deep understanding of the important factors in X-ray data collection from macromolecular crystals and can propose strategies suitable for various applications.
Different data collection approaches may affect data quality, which is closely related to the faithful interpretation of the final 3D structure model. Creative Biostructure can collect multiple datasets according to various phase determination methods, such as Molecular Replacement (MR), Multiple Isomorphous Replacement (MIR), Single-wavelength Anomalous Dispersion (SAD), and Multi-wavelength Anomalous Dispersion (MAD).
With a comprehensive X-ray crystallography platform, Creative Biostructure can offer integrated X-ray crystallography pipelines. Our mission is to provide state-of-the-art structural biology services to researchers in industry and academia. If you are interested in our X-ray diffraction data collection service, please feel free to contact us for more information or a detailed quote.