Drug Discovery

Inquiry

Cryogenic electron microscopy (cryo-EM) is a powerful analysis method for biological molecule assembly. After flash freezing, the biological macromolecules exist in amorphous ice with a nearly natural state. After data collection and processing, high-resolution molecular structures are obtained and can be analyzed to identify potential drug molecules. Cryo-EM is a perfect fit for basic research in structural biology and helps accelerate structure-based drug discovery.

Drug Discovery Figure 1. Structure of tetrameric 3a in lipid nanodiscs. (Kern D M, et al. 2021)

New diseases or emergent epidemics require de novo drug design, which requires the accumulation of a large amount of basic research. In the field of drug development, cryo-EM technology has been used for drug discovery. Although it is a cutting-edge technology, there are already structure-based drugs developed using cryo-EM in clinical trials, such as the COVID-19 antibody "cocktail".

We are very happy to cooperate with research institutions and companies for potential drug discovery. We believe that cryo-EM is playing an increasingly important role in structure-based drug design, advanced structure characterization of biologics, and quality control during cold-chain transportation. Our experts have years of experience in cryo-EM and can assist you with every step from sample preparation to data processing.