Structural Research of Cytokine Receptors

The realm of immunology is heavily reliant on the study of cytokine receptors, an area of research that holds great importance. These receptors act as messengers between immune cells and are responsible for regulating the immune system's responses. Due to their diverse protein composition, cytokine receptors present a challenge to the field of immunology in terms of their study.

Recent advancements have brought to light the architecture of cytokine receptors, with a particular emphasis on the IL-17 receptor family comprising of IL-17RA and IL-17RC. This receptor family is vital in triggering immune responses and inflammation, and its involvement has been identified in the pathogenesis of autoimmune diseases. Researchers focused their attention on the interplay between IL-17F and its receptors, IL-17RA and IL-17RC. Their findings revealed that IL-17F can bind with IL-17RC to form a homodimeric complex, thereby leading to IL-17RA-independent signaling, which ultimately induces a set of gene expression patterns that differ from those caused by IL-17RA-dependent signaling. These results bear great significance as they aid in understanding the role of IL-17F in promoting inflammation and immune responses. The findings also have the potential to facilitate the development of novel therapies for inflammatory diseases.

Figure 1. IL-17RC forms a symmetrical complex with IL-17F. (Goepfert A, et al., 2020)

Table 1. Structural Research of Cytokine Receptors.

The significance of structural analysis services in the study of complex proteins, such as cytokine receptors, cannot be understated. At Creative Biostructure, we take pride in providing an array of structural analysis services that aid researchers in comprehending the structure and function of cytokine receptors better. Our services include a multitude of techniques, such as X-ray crystallography, cryo-electron microscopy, nuclear magnetic resonance (NMR) spectroscopy, and computational modeling, that enable us to precisely determine protein structures, including cytokine receptors, and garner insights into their function.

We work hand-in-hand with our clients to develop tailor-made experiments that cater to their specific research needs. Our team of veteran scientists boasts extensive experience working with cytokine receptors and other intricate proteins, and we are unwavering in our commitment to delivering unparalleled structural analysis services. If you're looking to attain your research objectives, reach out to us and discover more about our structural analysis services.

Reference

1. Goepfert A, et al. Structural analysis reveals that the cytokine IL-17F forms a homodimeric complex with receptor IL-17RC to drive IL-17RA-independent signaling. Immunity. 2020, 52(3): 499-512. e5.