Structural Research of Bacterial Cell Division Proteins

Bacterial cell division, the process by which one parent cell divides into two identical daughter cells, is a highly regulated process to ensure proper segregation of genetic material. Disturbance of this process could lead to the formation of abnormal cells, which in turn could have serious implications for bacterial survival. Over the years, there has been a significant leap in the understanding of molecular mechanisms that underlie bacterial cell division, with a particular emphasis on structural and functional characterization of critical proteins involved in the process.

In the scope of bacterial cell division, one of the primary proteins is CrgA. CrgA is discovered in Mycobacterium tuberculosis, the bacterium responsible for causing tuberculosis. A recent study utilized X-ray crystallography and NMR spectroscopy to decipher the structure of CrgA embedded in lipid bilayers. Findings from the study showed that CrgA forms a dimeric structure that interacts with lipid bilayers and FtsZ, another protein that plays a critical role in bacterial cell division.

Figure 1. The structure of Mtb CrgA as a platform for assembling other interacting proteins. (Das N, et al., 2015)

Table 1. Structural Research of Bacterial Cell Division Proteins.

At Creative Biostructure, we take pride in offering a comprehensive suite of advanced structural analysis services for proteins. Our cutting-edge techniques, including X-ray crystallography, NMR spectroscopy, and cryo-electron microscopy, allow us to delve deep into the three-dimensional structure of proteins and provide valuable insights into their function and regulation. Our state-of-the-art facility boasts the latest technology for structural analysis, and our expert team is dedicated to delivering timely and accurate results to our clients. We understand the urgency of our clients’ needs, and we take an individualized approach to every project, working collaboratively to ensure that we meet their specific requirements. In addition to our commitment to high-quality results, we offer competitive pricing and flexible service options tailored to meet the diverse needs of our clients.

Our experienced scientists are available to address any questions or concerns you may have, and we are committed to advancing the field of structural analysis of proteins through our collaboration with clients. Whether you are interested in using our services to accelerate your research, or seeking to understand the complexity of the structural world of proteins, we welcome you to contact us and take advantage of our professional and comprehensive solutions.

Reference

1. Das N, et al. Structure of CrgA, a cell division structural and regulatory protein from Mycobacterium tuberculosis, in lipid bilayers. Proceedings of the National Academy of Sciences. 2015, 112(2): E119-E126.