Mempro™ Human Papillomavirus (HPV) for Virus-Like Particles (VLPs)
With years of experience in virus-like particles (VLPs) research, Creative Biostructure can provide customized Mempro™ VLPs derived from Human papillomavirus (HPV). Scientists from Creative Biostructure offer various services from VLPs design & production to VLPs characterization of HPV.
VLPs are multiprotein nanostructures or multiprotein formed from viral structural proteins, but don’t have any DNA or RNA. These spontaneously occurring bionanomaterials usually simulate the conformation of real viruses. Due to the special feature of VLPs, they are important in the progress of vaccines, virus research, therapy and lipoparticle technology.
HPV is a DNA virus from the papillomavirus family, it contains approximate 150 members and each virus is given a number called its HPV type. It is different from HIV and HSV (herpes), indeed, it is so common that almost all sexually active women and men get it at one point in their lives. There are a number of different types of HPV, some can cause genital warts while some lead to cancers, especially cervical cancer.
Figure 1. Packing of capsomeres on the HPV viral surface. (The EMBO Journal 2002)
- Genome Structure of Human Papillomavirus (HPV)
The genome of HPV is quite small with about 8000 base pairs and its life cycle severely goes after the differentiation program of the host keratinocyte. It is said that the HPV virion infects epithelial tissues via micro-abrasions, under this routes the virion connects with putative receptors, resulting in the access of virions into basal epithelial cells. Meanwhile, the viral genome is transported to the nucleus through unsuspected approaches. The basal cells of stratified epithelium are crucial factor limited HPV infection. The virus combines to epithelial tissues instead of live tissues by means of micro-abrasions or other epithelial trauma.
- Infection of Human Papillomavirus (HPV)
The initiation of transcription of HPV requiring 12–24 hours, so the infectious process is tardily. In general, HPV lesions are supposed to arise from the proliferation of infected basal keratinocytes. When the infectious viruses come across basal cells in the host, infection representatively occurs. HPV infection leads to the release of viral particles due to the degeneration of desquamating cells. Under the circumstances of low temperatures, HPV can survive for numerous months without a host, hence, the virus can be spread by walking barefoot when an individual have plantar warts.
Creative Biostructure provides high quality Mempro™ VLPs of HPV based on the progressive VLPs platform established for years. Please feel free to contact us for a detailed quote.
References:
Furumoto H, Irahara M. Human papilloma virus (HPV) and cervical cancer[J]. Journal of Medical Investigation, 2002, 49(3/4): 124-133.
Ljubojevic S, Skerlev M. HPV-associated diseases[J]. Clinics in dermatology, 2014, 32(2): 227-234.
Munoz N, Bosch F X, De Sanjose S, et al. The causal link between human papillomavirus and invasive cervical cancer: A population‐based case‐control study in colombia and spain[J]. International Journal of Cancer, 1992, 52(5): 743-749.
Mucocutaneous Manifestations of Viral Diseases: An Illustrated Guide to Diagnosis and Management[M]. CRC press, 2016.
