Liposomes for Analgesics

Creative Biostructure has years of experience in developing liposome formulations to provide efficient drug delivery platforms for various therapeutic agents including analgesics. Our expertise and superior resources will greatly assist your research in analgesics development.

Why use liposomes in analgesics?

Currently available local anesthetics have relatively short half-life, and may cause severe systemic adverse effects. This problem could be circumvented, in large part, by encapsulating drug molecules in liposomes, which allows for controlled release of the therapeutic agents. Encapsulation can also alter the spatial and temporal distribution of the drug molecules in human body resulting in significant attenuation of unwanted side effects, and thereby increasing drug compliance and efficiency of the treatment. The huge advantage of encapsulating analgesics drugs in liposomes has been demonstrated in chronic pain management. Bupivacaine is a local anesthetic commonly used in short-term postsurgical analgesia. A major drawback of bupivacaine and other local anesthetics is the moderate duration of action, averaging 8 to 12 hours. Liposomal encapsulation has substantially improved the functional properties--most importantly, the duration of Bupivacaine. By loading the drug molecules in multivesicular liposomes, the terminal half-life of liposomal bupivacaine has been increased by 9.8 folds compared to that of plain bupivacaine. Inspired by this, Creative Biostructure has developed a reliable system for liposome production and drug encapsulation to enable rapid design and evaluation of various liposomes and their encapsulation efficiency.

Figure 1. Morphology of multivesicular liposomes. (Pharmacological Reviews, 2016)

Our multivesicular liposome technology platform provides high quality and customizable services for your analgesics development.

• Formulation design and encapsulation of liposomal analgesic.
• Physical properties characterization of liposomal analgesic.
• Experiments design for pharmacokinetic study in vitro and in vivo.

Complete documentation package and technical consultation. Creative Biostructure’s powerful multivesicular liposome techniques offers a reliable choice for your studies on drug delivery systems. We provide the high-quality one-stop solution to settle any difficulty in your research. Please contact us to share more details, our services can always be tailored to meet your satisfaction.

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References

1. Eugene R. Viscusi, Raymond Sinatra, Erol Onel. (2014) The safety of liposome bupivacaine, a novel local analgesic formulation. Clin J Pain. 30: 102-110.
2. Golf M, Daniels SE, Onel E. (2011) A phase 3, randomized, placebocontrolled trial of DepoFoam(R) bupivacaine (extendedrelease bupivacaine local analgesic) in bunionectomy. Adv Ther. 28:776–788.
3. Hadis Daraee, Ali Etemadi, Mohammad Kouhi et al. (2016) Application of liposomes in medicine and drug delivery. Artif Cells Nanomed Biotechnol. 44:381-39.