PDE2A Protein Crystal(CBCRY48)
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| Product Summary | |
|---|---|
| Name | PDE2A Protein Crystal |
Download Datasheet
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| Cat No. | CBCRY48 |
| Fragment | Residues 215-900 |
| Protein Description | Phosphodiesterase 2 |
| Background | The phosphodiesterases (PDEs) are a superfamily of enzymes that metabolically inactivate cAMP and cGMP to play key roles in both these aspects of regulation. There are 11 PDE gene families, which differ broadly in specificity and affinity for cAMP and cGMP. An isoform PDE2A2 is supposed to regulates mitochondrial cAMP levels and respiration. |
| Protein Classification | Hydrolase |
| Structure Weight | 158085.17 Da |
| Method | X-Ray Diffraction |
| Resolution | 3.02 Å |
| Ligand Chemical Component | Mg2+ Zn2+ |
| Reference | Pandit J, Forman MD, Fennell KF, Dillman KS, Menniti FS. Mechanism for the allosteric regulation of phosphodiesterase 2a deduced from the x-ray structure of a near full-length construct. Proc.Natl.Acad.Sci.Usa (2009) 106 p.18225 |
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