MARK3 Protein Crystal(CBCRY42)
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| Product Summary | |
|---|---|
| Name | MARK3 Protein Crystal |
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| Cat No. | CBCRY42 |
| Fragment | Kinase and Ubiquitin-associated domains |
| Protein Description | MAP/microtubule Affinity-regulating Kinase 3 |
| Background | The protein encoded by MARK3 is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Microtubule affinity-regulating kinase 3 phosphorylates CDC25C on 'Ser-216'. It regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. |
| Protein Classification | Transferase |
| Structure Weight | 75337.80 Da |
| Method | X-Ray Diffraction |
| Resolution | 2.70 Å |
| Reference | Murphy, J.M., Korzhnev, D.M., Ceccarelli, D.F., Briant, D.J., Zarrine-Afsar, A., Sicheri, F., Kay, L.E., Pawson, T. Conformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domain. (2007) Proc.Natl.Acad.Sci.Usa 104: 14336-14341 |
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