Kv4.3 with KChIP1 Protein Crystal(CBCRY08)
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| Product Summary | |
|---|---|
| Name | Kv4.3 with KChIP1 Protein Crystal |
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| Cat No. | CBCRY08 |
| Fragment | N-terminal domain Residues 6-145 |
| Protein Description | Potassium channel Kv4.3 complexed with regulatory subunit KChIP1 |
| Background | The structure reveals a unique clamping action of the complex, in which a single KChIP1 molecule, as a monomer, laterally clamps two neighboring Kv4.3 N-termini in a 4:4 manner, forming an octamer. The proximal N-terminal peptide of Kv4.3 is sequestered by its binding to an elongated groove on the surface of KChIP1, which is indispensable for the modulation of Kv4.3 by KChIP1, and the same KChIP1 molecule binds to an adjacent T1 domain to stabilize the tetrameric Kv4.3 channels. |
| Protein Classification | membrane protein |
| Structure Weight | 75748.88 Da |
| Method | X-Ray Diffraction |
| Resolution | 3.2 Å |
| Ligand Chemical Component | Calcium ion; Zinc ion |
| Reference | Wang, H., Yan, Y., Liu, Q., Huang, Y., Shen, Y., Chen, L., Chen, Y., Yang, Q., Hao, Q., Wang, K., Chai, J. (2007) Structural basis for modulation of Kv4 K(+) channels by auxiliary KChIP subunits. Nat.Neurosci. 10: 32-39 |
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