HQExo™ Exosome-JM1(Exo-IC02)
| Product Summary | |
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| Name | HQExo™ Exosome-JM1 |
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| Cat No. | Exo-IC02 |
| Source | Exosome derived from human T pre-B lymphoblast cell line (JM1) |
| Product Overview | Exosomes are small membrane-extracellular vesicles (30-160 nm in diameter) produced from multivesicular bodies and play a crucial role in intercellular signaling and communication. Exosomes from immune cells can regulate immune responses of recipient cells，which becomes a great promise in cancer immunotherapy because of their immunogenicity and molecular transfer function. The cargoes carried on exosomes have been identified, which contains miRNA and mRNA molecules, peptides, proteins, cytokines and lipids. Exosomes derived from tumor cells and immune cells are directly influence the phenotype and immune-regulation functions of targeted cells. HQExo™ exosomes derived from immune-related cell lines could use as positive controls for exosome isolation and functional research, such as ELISA, FACS, WB. With the huge potential for cancer immunotherapy, exosome become the most effective cancer vaccines. Based on its molecular transfer function, high biocompatibility and low cytotoxicity to normal tissue, exosomes become a promising carrier for therapeutic molecular delivery system for anti-cancer treatment. Exosome can be purified from the cell culture by ultracentrifugation or precipitation techniques, and characterized by nanoparticles tracking analysis (NTA) and ELISA or WB. Frozen liquid should be kept at -20°C to -80°C for a long-term stability. Creative Biostructure standard exosome products guarantee higher purity and quality to meet our customer’s downstream analyses. |
| Form | Frozen liquid |
| Concentration | >1x10^6 particles |
| Storage | Store at -20°C or colder. Recommend to avoid repeated freeze-and-thaw cycles. |
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Frequently Asked Questions
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Do quiescent cells secrete exosomes?
Yes, quiescent cells are known to secrete exosomes. Exosomes are small vesicles that are released by various types of cells, including both quiescent (non-dividing) and actively dividing cells. These vesicles are involved in cell-to-cell communication, as they carry a cargo of proteins, lipids, and nucleic acids that can be transferred to recipient cells.
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What strategies can be employed to standardize mRNA expression within exosomes?
You can utilize miRNA genes like miRNA16, miRNA26a, miRNA221, miRNA22, miRNA181a, miRNA181c, miRNA103, miRNA191, let7d, as well as small RNAs (5SrRNA and U6snRNA) that are normally expressed in exosomes.
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Do you offer items designed for conducting studies on tracking extracellular vesicles?
Creative Biostructure offers highly purified fluorescent exosome standards for tracking EVs in fluorescence microscopy experiments. These fluorescent exosomes are labeled with a green dye, ensuring stable fluorescent labeling. They are suitable for various applications, providing a long-lasting and well-visible signal.
