PPARG Protein Crystal(CBCRY34)
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| Product Summary | |
|---|---|
| Name | PPARG Protein Crystal |
Download Datasheet
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| Cat No. | CBCRY34 |
| Fragment | Ligand binding domain |
| Protein Description | Peroxisome Proliferator-activated Receptor Gamma |
| Background | PPARG regulates fatty acid storage and glucose metabolism. Many insulin sensitizing drugs used in the treatment of diabetes target PPARG as a means to lower serum glucose without increasing pancreatic insulin secretion. The genes activated by PPARG stimulate lipid uptake and adipogenesis by fat cells. PPARG knockout mice fail to generate adipose tissue when fed a high fat diet. |
| Protein Classification | transcription |
| Structure Weight | 34246.95 Da |
| Method | X-Ray Diffraction |
| Resolution | 2.27Å |
| Ligand Chemical Component | ZAA |
| Reference | Zhang, H., Ryono, D.E., Devasthale, P., Wang, W., O`Malley, K., Farrelly, D., Gu, L., Harrity, T., Cap, M., Chu, C., Locke, K., Zhang, L., Lippy, J., Kunselman, L., Morgan, N., Flynn, N., Moore, L., Hosagrahara, V., Zhang, L., Kadiyala, P., Xu, C., Doweyko, A.M., Bell, A., Chang, C., Muckelbauer, J., Zahler, R., Hariharan, N., Cheng, P.T. (2009) Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists. Bioorg |
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