PLK3 Protein Crystal(CBCRY55)
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| Product Summary | |
|---|---|
| Name | PLK3 Protein Crystal |
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| Cat No. | CBCRY55 |
| Fragment | Polo box domain |
| Protein Description | Polo-like Kinase 3 |
| Background | Polo-like kinase 3 (PLK3) is a member of the highly conserved polo-like kinase family of serine/threonine kinases that are critical regulators of cell cycle progression, mitosis, cytokinesis, and the DNA damage response. Members of this family are characterized by an amino-terminal kinase domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. This gene has also been implicated in stress responses and double-strand break repair. In human cell lines, this protein is reported to associate with centrosomes in a microtubule-dependent manner, and during mitosis, the protein becomes localized to the mitotic apparatus. |
| Protein Classification | Transferase |
| Structure Weight | 32791.14 Da |
| Method | X-Ray Diffraction |
| Resolution | 1.90 Å |
| Ligand Chemical Component | SULFATE ION, 9ZP |
| Reference | Brown K, Charrier JD, Durrant S, Griffiths M, Hudson C, Kay D, Knegtel R, Odonnell M, Pierard F, Twin H, Weber P, Young S. Discovery of oral polo-like kinase (Plk) inhibitors with enhanced selectivity profile using residue targeted drug design. No recorded citation in PubMed |
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