PGAM1 Protein Crystal(CBCRY11)
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| Product Summary | |
|---|---|
| Name | PGAM1 Protein Crystal |
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| Cat No. | CBCRY11 |
| Fragment | Full length |
| Protein Description | Phosphoglycerate Mutase 1 |
| Background | The B-type cofactor-dependent phosphoglycerate mutase (dPGM-B) catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate in glycolysis and gluconeogenesis pathways using 2,3-bisphosphoglycerate as the cofactor. The crystal structures of human dPGM-B bound with citrate were determined in two crystal forms. These structures reveal a dimerization mode conserved in both of dPGM and BPGM (bisphosphoglycerate mutase), based on which a dPGM/BPGM heterodimer structure is proposed. Structural comparison supports that the conformational changes of residues 13-21 and 98-117 determine PGM/BPGM activity differences. |
| Protein Classification | isomerase hydrase |
| Structure Weight | 361525.84 Da |
| Method | X-Ray Diffraction |
| Resolution | 2.8 Å |
| Ligand Chemical Component | citric acid; chloride ion |
| Reference | Wang, Y., Wei, Z., Liu, L., Cheng, Z., Lin, Y., Ji, F., Gong, W. (2005) Crystal structure of human B-type phosphoglycerate mutase bound with citrate. Biochem.Biophys.Res.Commun. 331: 1207-1215 |
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