PDXK Protein Crystal(CBCRY19)
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| Product Summary | |
|---|---|
| Name | PDXK Protein Crystal |
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| Cat No. | CBCRY19 |
| Fragment | Full length |
| Protein Description | Pyridoxal kinase |
| Background | Pyridoxal kinase, a member of the ribokinase superfamily, catalyzes the ATP-dependent phosphorylation reaction of vitamin B6 and is an essential enzyme in the formation of pyridoxal-5'-phosphate, a key cofactor for over 100 enzymes. Pyridoxal kinase is thus regarded as a potential target for pharmacological agents. Structure comparison reveals that the key 12-residue peptide over the active site in HPLK is a beta-strand/loop/beta-strand flap, while the corresponding peptide in sheep brain enzyme adopts a loop conformation. Moreover, HPLK possesses a more hydrophobic ATP-binding pocket. |
| Protein Classification | Transferase |
| Structure Weight | 74135.20 Da |
| Method | X-Ray Diffraction |
| Resolution | 2.8Å |
| Reference | Cao, P., Gong, Y., Tang, L., Leung, Y.C., Jiang, T. (2006) Crystal structure of human pyridoxal kinase J.Struct.Biol. 154: 327-332 |
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