MAD2 with p31 Protein Crystal(CBCRY03)
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| Product Summary | |
|---|---|
| Name | MAD2 with p31 Protein Crystal |
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| Cat No. | CBCRY03 |
| Fragment | Full length Residues 36-274 |
| Protein Description | Mad2 complexed with p31(comet) |
| Background | The crystal structure of the Mad2-p31(comet) complex is reported. The C-terminal region of Mad2 that undergoes rearrangement in different Mad2 conformers is a major structural determinant for p31(comet) binding, explaining the specificity of p31(comet) toward Mad1- or Cdc20-bound Mad2. p31(comet) adopts a fold strikingly similar to that of Mad2 and binds at the dimerization interface of Mad2. Thus, p31(comet) exploits the two-state behavior of Mad2 to block its activation by acting as an \"anti-Mad2.\" |
| Protein Classification | cell cycle |
| Structure Weight | 105471.24 Da |
| Method | X-Ray Diffraction |
| Resolution | 2.30 Å |
| Reference | Yang, M., Li, B., Tomchick, D.R., Machius, M., Rizo, J., Yu, H., Luo, X. p31comet blocks Mad2 activation through structural mimicry.Cell(Cambridge,Mass.)2007; 131: 744-755 |
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