COTL1 Protein Crystal(CBCRY15)
Inquiry
| Product Summary | |
|---|---|
| Name | COTL1 Protein Crystal |
Download Datasheet
|
|
| Cat No. | CBCRY15 |
| Fragment | Full length |
| Protein Description | Coactosin-like protein |
| Background | Human coactosin-like protein is an actin filament binding protein but does not bind to globular actin. It associates with 5-Lipoxygenase both in vivo and in vitro, playing important roles in modulating the activities of actin and 5-Lipoxygenase. Coactosin counteracts the capping activity of capping protein which inhibits the actin polymerization. The structure showed a high level of similarity to ADF-H domain, although their amino acid sequences share low degree of homology. A few conserved hydrophobic residues that may contribute to the folding were identified. This structure suggests coactosin-like protein bind to F-actin in a different way from ADF/Cofilin family. Combined with the information from previous mutagenesis studies, the binding sites for F-actin and 5-Lipoxygenase were analyzed, respectively. These two sites are quite close, which might prevent F-actin and 5-Lipoxygenase from binding to coactosin simultaneously. |
| Protein Classification | protein binding |
| Structure Weight | 31763.60 Da |
| Method | X-Ray Diffraction |
| Resolution | 2.8 Å |
| Reference | Liu, L., Wei, Z., Wang, Y., Wan, M., Cheng, Z., Gong, W. (2004) Crystal Structure of Human Coactosin-like Protein J.Mol.Biol. 344: 317-323 |
Online Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
