ARHGEF7 Protein Crystal(CBCRY28)
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| Product Summary | |
|---|---|
| Name | ARHGEF7 Protein Crystal |
Download Datasheet
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| Cat No. | CBCRY28 |
| Fragment | SH3 domain |
| Protein Description | Rho Guanine Nucleotide Exchange Factor 7 |
| Background | Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene, but some of their full-length sequences have not been determined. |
| Protein Classification | Signaling Protein |
| Structure Weight | 15255.28 Da |
| Method | X-Ray Diffraction |
| Resolution | 2.01Å |
| Ligand Chemical Component | Chloride ion; Mercury ion |
| Reference | Li, X., Liu, X., Sun, F., Gao, J., Zhou, H., Gao, G.F., Bartlam, M., Rao, Z. (2006) Crystal structure of the N-terminal SH3 domain of mouse betaPIX, p21-activated kinase-interacting exchange factor Biochem. Biophys. Res. Commun. 339: 407-414 |
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