AR Protein Crystal(CBCRY23)
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| Product Summary | |
|---|---|
| Name | AR Protein Crystal |
Download Datasheet
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| Cat No. | CBCRY23 |
| Fragment | Residues 669-918 |
| Protein Description | Androgen Receptor |
| Background | Androgen receptor (AR) is a ligand-inducible steroid hormone receptor that mediates androgen action, determining male sexual phenotypes and promoting spermatogenesis. As the androgens play a dominant role in male sexual development and function, steroidal androgen agonists have been used clinically for some years. However, there is a risk of potential side effects and most steroidal androgens cannot be dosed orally, which limits the use of these substances. 1,2-Dihydro-6-N,N-bis(2,2,2-trifluoroethyl)amino-4-trifluoromethyl-2-quinolinone (LGD2226) is a synthetic nonsteroidal ligand and a novel selective AR modulator. |
| Protein Classification | Ligand Binding Protein |
| Structure Weight | 29541.62 Da |
| Method | X-Ray Diffraction |
| Resolution | 2.8Å |
| Ligand Chemical Component | 6-[Bis(2,2,2-Trifluoroethyl)Amino]-4-(Trifluoromethyl)quinolin-2(1H)-one. |
| Reference | Wang, F., Liu, X.-Q., Li, H., Liang, K.-N., Miner, J.N., Hong, M., Kallel, E.A., van Oeveren, A., Zhi, L., Jiang, T. (2006) Structure of the ligand-binding domain (LBD) of human androgen receptor in complex with a selective modulator LGD2226 ACTA CRYSTALLOGR.,SECT.F 62: 1067-1071 |
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