Exosome Microbiomics Analysis Service

To gain a deeper understanding of the intricate relationships between microorganisms and host cells, Creative Biostructure offers comprehensive exosome microbiomics analysis services. Our expert team leverages cutting-edge exosome analysis technology to deliver precise and detailed insights that are crucial for exploring novel disease markers and therapeutic targets.

Why Conduct Exosome Microbiomics Analysis?

Understanding Host-Microorganism Interactions

• Exosomes as Defense Mechanisms: Exosomes play a crucial role in the host's defense against microorganisms. They can carry immune-related molecules such as antimicrobial peptides and antibodies to inhibit the growth and reproduction of pathogens. Additionally, exosomes can encapsulate and remove microorganisms to prevent further infection.
• Microorganisms Influencing Exosomes: Some microorganisms can induce host cells to produce specific types of exosomes carrying signaling molecules related to microbial infection. This modulation can help in regulating the host immune response and may facilitate the microorganism's survival and reproduction in host cells.

Exploring Microbial Infections and Immune Responses

• Studying Cross-Cellular Transmission: Microorganisms can attach to exosomes and use them as vehicles to enter other cells, achieving cross-cellular transmission. Understanding this process can provide insights into how infections spread and persist within the host.
• Impact on Intercellular Communication: Microorganisms can directly interfere with the release and delivery of exosomes, thus affecting intercellular communication and material exchange. Analyzing these interactions can advance our understanding of pathogenic strategies and host defenses.

Identifying Disease Markers and Therapeutic Targets

• Discovery of New Disease Markers: By analyzing the microbiomics of exosomes, researchers can identify new biomarkers for microbial infections. These biomarkers can be used for early disease detection and monitoring.
• Developing Therapeutic Targets: The detailed study of exosome-microorganism interactions can unveil potential therapeutic targets. Understanding how microorganisms exploit exosomes and how host cells respond can lead to the development of innovative treatment strategies.

Exosome Microbiomics Analysis at Creative Biostructure

Our exosome microbiomics analysis service utilizes cutting-edge molecular technologies to explore the complex interactions between exosomes and microorganisms, providing insights into host defense mechanisms, microbial influence on exosome production, and potential new therapeutic targets.

Figure 1. Universal microbiome testing principle. (Fukuda K, et al., 2016).

Leveraging our extensive project experience in the field of exosomes, Creative Biostructure is committed to providing customers with accurate and comprehensive exosome microbiomics data support. If you are interested in our services, please contact us for a detailed quote.

Key Advantages of Our Services

• Cutting-Edge Molecular Detection: We employ a range of molecular techniques targeting the 16S rRNA gene, including FISH, Q-PCR, T-RFLP, and DGGE. These methods offer a robust approach to detect and quantify microorganisms, providing a detailed profile of the microbial community within the sample.
• Integration with Exosome Research: Our unique approach integrates microbial data with exosome studies, exploring the intricate relationship between microorganisms and exosome production, release, and function. This provides a holistic view of the interactions within the host-microbe interface.
• Expert Data Analysis and Interpretation: We provide detailed reports and offer consultation services to help clients understand the implications of their results. Our service not only aids in the discovery of new disease markers and therapeutic targets but also contributes to a deeper understanding of the mechanisms of microbial infection.
• Customizable Service: We offer a customizable service that can be tailored to specific research questions. This flexibility ensures that our clients receive the most relevant and valuable analysis for their unique requirements.

Resources

• Brochures
• Case Studies
• Citations
• Support Knowledge

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1. Al-shubaily, Fawzia A., and Maryam H. Al-Zahrani. "Characterization and Fine Structure of Exosomes." Role of Exosomes in Biological Communication Systems (2021): 27-75.

   … Creative Biostructure provides a sensitive technology for exosome characterization to gain more information and accelerating the use of exosome biology in diagnostic tests or clinical …

2. Liang, Chenyu, et al. "Exosomes of human umbilical cord MSCs protect against hypoxia/reoxygenation-induced pyroptosis of cardiomyocytes via the miRNA-100-5p/FOXO3/NLRP3 pathway." Frontiers in Bioengineering and Biotechnology 8 (2021): 615850.

   … Extracted exosomes were checked using transmission electron microscopy (TEM) (MagHelix, Creative Biostructure, Shirley, NY) …

3. Bickmore, Diana C., and John J. Miklavcic. "Characterization of extracellular vesicles isolated from human milk using a precipitation-based method." Frontiers in nutrition 7 (2020): 22.

   … Fatty acid analysis was performed by Creative Biostructure (Shirley, NY USA) …

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Based on the great promise of exosomes as a tool for disease diagnosis and management, it is essential to isolate exosomes from various biological matrices efficiently, simply, and economically…

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Exosome characterization offers tremendous clinical opportunities in the field of liquid biopsy. This potential requires high precision and reproducibility in the detection and characterization of exosomes…

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Multi-omics Technologies in Exosome Analysis

Multi-omics approaches, such as proteomics, transcriptomics, and metabolomics, allow for detailed characterization of the various biomolecules (proteins, RNAs, lipids, and metabolites) present in exosomes, revealing the diverse functions and potential therapeutic applications of exosomes...

Frequently Asked Questions

• How does your analytical technology ensure the accuracy of exosome microbiomics data?

  Our advanced techniques include next-generation sequencing, mass spectrometry, and bioinformatics analysis. These technologies ensure accurate and comprehensive data capture, reducing the likelihood of errors and providing reliable results. Our team of experts has extensive experience in the field, ensuring that every step, from sample preparation to data interpretation, is executed with the utmost precision.

• What types of samples are compatible with your service, and are there any special requirements for sample preparation?

  Our service is compatible with a wide range of biological samples, including but not limited to blood, urine, and tissue samples. We will provide you with clear guidelines for sample collection and preparation to ensure the integrity of the exosomes and the accuracy of the analysis.

• What is the typical turnaround time for your exosome microbiomics analysis service?

  Our standard turnaround time is typically within 4-6 weeks from the receipt of the sample. However, this can vary depending on the complexity of the analysis and the specific requirements of your project. We will provide you with a detailed timeline at the outset of the project.

Ordering Process

References

1. Fukuda K, Ogawa M, Taniguchi H, et al. Molecular approaches to studying microbial communities: targeting the 16S ribosomal RNA gene. Journal of UOEH. 2016. 38(3): 223-232.
2. Hou K, Wu Z X, Chen X Y, et al. Microbiota in health and diseases. Signal Transduction and Targeted Therapy. 2022. 7(1): 1-28.