Exosome Services
Exosomes become a promising carrier for therapeutic molecular delivery especially for cancer treatment due to their low immunogenicity, high
biocompatibility, high drug delivery efficacy, and low cytotoxicity to normal tissue. First of all, exosomes are naturally endowed with efficient targeting
surface moieties for tumor sites. Furthermore, exosome engineering could help its selective accumulation in cancer sites. As a therapeutic drug delivery
carrier for cancer treatment, exosomes exhibit increased cytotoxicity and higher killing efficacy on cancer cells.
Figure 1. Modification strategy and effect of tumor-derived
exosomes in cancer therapy. (You, Benshuai., et al. (2018) Am J Cancer Res. 8(8): 1332–1342.)
Besides the fact that exosomes are well-tolerated in vivo and naturally able to deliver functional biomolecules, exosomes are also relatively easy to engineer. It is worth to note that exosomes derived from different sources have diverse applications in exosome-based cancer treatment because they reflect the functional status of their parent cells. Thus, before we proceed with the exosome engineering, it is crucial for us to choose the appropriate exosomes as a starting point. Our scientists are ready to produce custom-engineered exosomes for you starts from different cell line-derived exosomes to diverse modifications with your cargos for a specific cell type targeting.
Exosome Services at Creative Biostructure
Why Partner with Creative Biostructure?
- Equipped with mature exosome isolation techniques to ensure efficient isolation of exosomes from different biological samples.
- Ability to analyze and characterize exosomal lipids, proteins and RNAs, such as exosomal lipidomics, exosomal metabolomics, exosomal proteomics and exosomal RNA sequencing.
- Provides a variety of labeling approaches to facilitate in vivo exosome tracking, biodistribution and kinetic research of exosomes.
- Customizable exosome services for specific downstream applications.
- One-stop solution from exosome isolation to data collection and analysis based on customer requirements.
Based on the comprehensive techniques in exosome engineering, Creative Biostructure offers state-of-the-art services to satisfy your demands on exosome application. Please contact us for more information.
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References
- You B, et al. Engineering exosomes: a new direction for anticancer treatment. American Journal of Cancer Research. 2018, 8(8): 1332.
- Yim N, et al. Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein–protein interaction module. Nature Communications. 2016, 7(1): 1-9.
- Sterzenbach U, et al. Engineered exosomes as vehicles for biologically active proteins. Molecular Therapy. 2017, 25(6): 1269-1278.
