Cryo-EM Solutions
With the rise of molecular biology, target-based drug discovery has gradually become the mainstream model of new drug development. Targets and binding sites of target-receptor interactions are usually obtained by structural biology methods. Target structures and binding sites are used as models for virtual screening, and the potential binding molecules are obtained through high-throughput screening methods.
Cryogenic electron microscopy (cryo-EM) is used for three-dimensional structure analysis of biological samples, including single particle analysis, microcrystal electron diffraction and cryo-electron tomography (Cryo-ET). It can be used for structure-based drug design, epitope mapping, and subcellular structure analysis. It has prospective significance in drug development and biological product development.
There are already some structurally developed drugs in clinical trials using cryo-electron microscopy, such as GSK novel inhibitor of Kala-azar for key enzymes in the parasite.
Figure 1. Cryo-EM of native human UMOD filaments reveals their unique polymeric
structure (left) at near-atomic resolution (top right), suggesting how the protein can form supramolecular sheets (bottom right) that facilitate the capture
of uropathogenic bacteria.
Cryo-EM applications:
- Structural biology research
- Conformation variability analysis
- Particle morphology analysis
- Subcellular structure analysis
- Epitope mapping
- Drug discovery
- Disease studies
- Cryo-EM technologies
Our service advantages:
- Facilitate rapid and efficient R&D of new drugs
- A team of experts with years of experience in scientific research
- Long-term continuous technical support services
- High throughput sample testing can be performed
- Simple and fast user interface, timely after-sales service
We provide services to both academia and pharmaceutical companies. If you are interested in our cryo-EM services, please feel free to contact us. We are looking forward to cooperating with you.
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