Aptamer-Based Exosome Targeting Service

Aptamer-based exosomes refer to a specialized type of exosomes covered with aptamers that can bind to specific receptors and deliver specific signals or substances. As an expert in exosome research, Creative Biostructure offers aptamer-based exosome targeting services, aiming to use aptamers to improve the targeted delivery effect of exosomes.

What is Aptamer-Based Exosome Targeting?

Exosomes are small membrane vesicles released outside cells, containing various biological macromolecules such as DNA, RNA, and proteins. Exosomes can be delivered through body fluid circulation and release their cargo on target cells, making them useful for drug delivery and therapy. Aptamers are oligonucleotides with a length of 20-100 nt, possessing a unique three-dimensional structure after folding, allowing them to specifically bind to a variety of targets, such as small molecules, biological macromolecules, subcellular components, tissues, and organs. Aptamers are often screened and optimized in vitro to exhibit high affinity and specificity.

Aptamer-based exosome targeting technology utilizes specific oligonucleotide molecules to selectively recognize and bind to specific antigens or receptors on target cells. Once the aptamer is combined with the exosomes, it is displayed on the surface, providing the exosomes with the ability to target specific antigens. This aptamer-based exosome targeting technology has potential applications in drug delivery, gene therapy, tumor diagnosis, and treatment. By loading drugs or genes, exosomes can be modified into nanoparticles targeting tumor cells, releasing the payload material on the target cells to improve therapeutic effects and reduce side effects. Additionally, because exosomes provide cellular information, they can serve as biomarkers for tumor diagnosis, disease progression monitoring, and treatment evaluation.

The aptamer-based exosome targeting service provided by Creative Biostructure enables exosomes to achieve targeted delivery of specific molecules by regulating the specific binding ability of aptamers. It finds wide applications in drug delivery, gene therapy, cancer diagnosis, etc., with promising prospects and potential.

Figure 1. Aptamer-Exosomes for Tumor Theranostics. (Yi, Kezhen, et al., 2021)

What are the Advantages of Aptamer-Based Exosome Targeting Technology?

• Highly Specific: Using the highly specific binding ability of aptamers, exosomes can be targeted to specific cells or tissues to improve the specificity of drug delivery.
• Efficiency: With their smaller particle size and longer circulation life, exosomes can efficiently cross cell membranes, thereby promoting drug internalization and targeted delivery. In addition, exosomes have a high drug-loading capacity and can encapsulate multiple drugs at the same time to improve drug release and efficacy.
• Biocompatibility: Aptamer-based exosomes, being secreted by cells, boast greater biocompatibility compared to traditional synthetic nanoparticles. This property helps reduce immune responses and mitigates toxic side effects.
• Controllability: Aptamer-based exosome targeting technology offers the ability to regulate drug delivery by adjusting the characteristics of aptamers and exosomes. Altering the structure and affinity of the aptamer changes the binding ability and targeting effect of both the aptamer and exosomes. Moreover, the regulation of drug release can be achieved through surface modification of exosomes or adjustments to the coating layer.

Highlights of Our Aptamer-Based Exosome Targeting Service

• Extensive Expertise in Exosome and Aptamer Research: Leverage our wealth of experience in both exosome and aptamer research, our dedicated team of experts possesses a deep understanding of the intricacies of exosome biology and aptamer technology, ensuring the highest quality and reliability in our services.
• Cost-Effective Solutions for Accurate Results: Our aptamer-based exosome targeting service offers the most precise results at a competitive price point, allowing you to achieve your research goals efficiently while optimizing your budget.
• One-Stop Exosome Services: From aptamer selection to the development of targeted delivery systems, we provide end-to-end solutions, streamlining the workflow for your exosome targeting studies.

Creative Biostructure has rich experience in exosome research with many years of successful project experience and industry leadership, and we can provide high-quality and innovative solutions to different customers. Please feel free to contact us for a detailed quote if you're interested in our services.

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Reference

1. Yi K, et al. Aptamer–exosomes for tumor theranostics. ACS Sensors. 2021, 6(4): 1418-1429.