Custom Membrane Protein Production

Inquiry

Membrane proteins play an essential role in life activities. In the sequenced genome, membrane proteins account for 30% of drug-targeted sites. Functions such as signal transmission between cells and detection of the external environment are mostly realized through special membrane receptor proteins on biological membranes. Many human diseases are related to the abnormal function of these membrane proteins. Membrane proteins are important drug targets, but their application is limited due to factors such as low expression, difficulty in preparation, and poor stability. With a professional membrane protein production team and rich experience in membrane protein production, Creative Biostructure can express and purify membrane proteins that are currently unavailable in the market (such as GPCRs, ion channels, transporters, enzymes, and viral targets).

What Membrane Proteins Can We Produce?

We can express but are not limited to the following membrane proteins:

Transmembrane Protein Production
5-Lipoxygenase-Activating Protein	HSD-11β	VEGF receptors
ABC Transporters	Hypoxia-induced Proteins	Aldehyde Dehydrogenases
ACBP	Immunoglobulins	Ammonia and Urea transporters
Amyloid beta (A4)	Insulin receptor	FMN-linked Oxidoreductases
Bcl-2 Inhibitors	Integrins	Leucine Rich Repeat (LRR)-Containing Transmembrane Proteins
BNIPs	Ion channel	Leukotriene C4 synthase
CAAX protease	MAPEG	Lysosome-associated membrane glycoprotein
Cytochromes P450	MFS	Major Intrinsic Protein (MIP)/FNT superfamily
E-NPPs	Mink Family	Microsomal prostaglandin E synthase
EPHA1	MPPs	N-(deoxy)ribosyltransferase-like Membrane Proteins
EPHA2	Peptidase AD	Neutral/alkaline Ceramidases
EPHA3	Peptidase Family M48	Oligosaccharyl Transferase
EPHA4	Peptidase MA	Pentameric Ligand-gated Ion Channels
Fatty Acid Desaturases	Protein Jagged	Rhodopsin-like receptors and pumps
Gamma secretase	Receptor-type Kinases	Single-helix ATPase Regulators
Glucose transporter	SNARE Complex	Squalene/ phytoene Synthase
Glycophorins	Sulfatases	Stearoyl -CoA desaturase 1
GPCR	TNF receptor	Stannin (SNN) Membrane Proteins
HER2/ErbB2	Transmembrane Proteins 14	T-cell Surface Glycoprotein CD3 Zeta Chain
HER3/ErbB3	Transporter	Tetratricopeptide repeat (TPR) Alpha-Helical Repeat Proteins
HER4/ErbB4	TROBP	Transmembrane Proteins with NAD(P)-binding Rossmann-fold Domains
Chemokine receptor 8

Monotypic/Peripheral Protein Production
Alpha/Beta-Hydrolase	FYVE/PHD Zinc Finger Protein	Phosphatidylinositol 3-/4-Kinase
Annexins	Galactose-Binding Domain-Like Protein	PLC-like Phosphodiesterase
Bet V1-Like Protein	Glycolipid Transfer Protein	Phosphotyrosine Protein Phosphatases II
C1 Domain-Containing Protein	Immunoglobulin-Like Superfamily (E Set) Protein	P-Loop Containing Nucleoside Triphosphate Hydrolase
C2 Domain-containing Protein	Lipocalin	Protein kinase superfamily
CoA-Dependent Acyltransferases	Lipoxygenase	PX Domain-Containing Protein
CRAL-TRIO Domain-Containing Protein	PGBD superfamily	Saposin
PH Domain-Like Protein	Synuclein	DNase I-like protein
Fibrinogen	Transcriptional factor tubby

Membrane Protein Peptides Production
Amyloid Beta-sheet Peptides	Peptide Fragments of Transmembrane Protein	Peptide fragments of water-soluble proteins
Membrane Anchor Helices of Peripheral Proteins

Advantages of Our Membrane Protein Production Service

Creative Biostructure has rich experience in membrane protein research, and the advantages of our service include the following:

Short Experimental Period: With optimized procedures, we can deliver the membrane proteins required by customers in the shortest time.
Various Expression Systems: We have a variety of membrane protein expression systems, and the most suitable system can be selected according to the needs of customers for the production of membrane proteins.
High Activity: Our platform enables membrane proteins to be crystallized while maintaining their native conformation and retaining their function and activity.
One-Stop Service: We provide one-stop membrane protein production services and can also offer membrane protein crystallization and cryo-electron microscopy services.

Creative Biostructure's scientists will assist you in all project stages of evaluation, planning, and execution. Each project is tailored to the customer's specifications of scale, purity, analytical characterization, and activity. We help our customers plan their projects in the most cost-efficient manner. Please feel free to contact us for a detailed quote.

Ordering Process